This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SFRP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SFRP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SFRP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:153,536,072–153,536,529 | 252.8 kb | Distal (>10kb) Multiome | 95 | |
| chr4:153,683,798–153,685,200 | 104.3 kb | Distal (>10kb) Multiome | 432 | |
| chr4:153,759,037–153,760,663 | 29.1 kb | Distal (>10kb) Multiome | 280 | |
| chr4:153,781,306–153,781,652 | 7.4 kb | Proximal (<10kb) | 39 | |
| chr4:153,781,759–153,782,081 | 7.0 kb | Proximal (<10kb) | 119 | |
| chr4:153,785,919–153,786,304 | 2.8 kb | Proximal (<10kb) | 70 | |
| chr4:153,786,404–153,786,674 | 2.4 kb | Proximal (<10kb) | 35 | |
| chr4:153,787,655–153,787,992 | 1.1 kb | Proximal (<10kb) | 23 | |
| chr4:153,788,102–153,793,304 | 75 bp | At TSS Multiome | 619 | |
| chr4:153,830,437–153,831,423 | 41.9 kb | Distal (>10kb) Multiome | 106 | |
| chr4:154,548,823–154,550,849 | 761.3 kb | Distal (>10kb) Multiome HiCAR | 633 |
Genomic view of the SFRP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.