Enables RNA binding activity and splicing factor binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U12-type spliceosomal complex and U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SF3B5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SF3B5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SF3B5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:143,842,515–143,843,902 | 252.3 kb | Distal (>10kb) Multiome | 1125 | |
| chr6:143,941,930–143,942,677 | 153.3 kb | Distal (>10kb) Multiome | 362 | |
| chr6:143,958,803–143,959,611 | 136.4 kb | Distal (>10kb) Multiome | 236 | |
| chr6:143,964,156–143,965,374 | 130.8 kb | Distal (>10kb) Multiome | 218 | |
| chr6:143,972,911–143,973,871 | 122.2 kb | Distal (>10kb) Multiome | 319 | |
| chr6:144,007,743–144,008,869 | 87.2 kb | Distal (>10kb) Multiome | 500 | |
| chr6:144,063,633–144,064,850 | 31.4 kb | Distal (>10kb) Multiome | 823 | |
| chr6:144,094,958–144,096,613 | 117 bp | At TSS Multiome | 1009 | |
| chr6:144,104,998–144,105,206 | 9.4 kb | Proximal (<10kb) | 156 | |
| chr6:144,149,717–144,151,586 | 54.9 kb | Distal (>10kb) Multiome | 708 | |
| chr6:144,215,237–144,217,057 | 120.8 kb | Distal (>10kb) Multiome | 1073 | |
| chr6:144,284,589–144,287,497 | 189.5 kb | Distal (>10kb) Multiome | 1050 | |
| chr6:144,330,551–144,331,098 | 235.2 kb | Distal (>10kb) Multiome | 251 |
Genomic view of the SF3B5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.