Transcription factors with Perturb-seq knockdown data for SETBP1-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SETBP1-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SETBP1-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:44,678,791–44,679,864 | at TSS | At TSS | 618 | |
| chr18:44,679,993–44,681,240 | 276 bp | At TSS | 477 | |
| chr18:44,682,167–44,683,592 | 2.5 kb | Proximal (<10kb) | 293 | |
| chr18:44,685,115–44,685,751 | 5.4 kb | Proximal (<10kb) | 12 |
Genomic view of the SETBP1-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.