The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for SET. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SET upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SET, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:128,420,259–128,421,260 | 263.1 kb | Distal (>10kb) Multiome | 701 | |
| chr9:128,455,721–128,456,522 | 227.8 kb | Distal (>10kb) Multiome | 684 | |
| chr9:128,504,482–128,505,188 | 179.1 kb | Distal (>10kb) Multiome | 766 | |
| chr9:128,552,006–128,553,125 | 131.3 kb | Distal (>10kb) Multiome | 839 | |
| chr9:128,656,436–128,657,126 | 27.0 kb | Distal (>10kb) Multiome | 1009 | |
| chr9:128,683,393–128,684,010 | 197 bp | At TSS Multiome | 296 | |
| chr9:128,684,170–128,684,813 | 903 bp | At TSS Multiome | 574 | |
| chr9:128,688,449–128,689,713 | 5.3 kb | Proximal (<10kb) Multiome | 805 | |
| chr9:128,702,246–128,702,946 | 18.7 kb | Distal (>10kb) Multiome | 720 | |
| chr9:128,723,691–128,725,229 | 40.4 kb | Distal (>10kb) Multiome | 821 | |
| chr9:128,771,658–128,772,301 | 88.2 kb | Distal (>10kb) Multiome | 940 | |
| chr9:128,786,928–128,787,516 | 103.4 kb | Distal (>10kb) Multiome | 1040 | |
| chr9:128,818,208–128,819,406 | 134.6 kb | Distal (>10kb) Multiome | 839 | |
| chr9:128,829,505–128,830,189 | 146.0 kb | Distal (>10kb) Multiome | 782 | |
| chr9:128,881,863–128,882,454 | 198.2 kb | Distal (>10kb) Multiome | 777 | |
| chr9:128,921,941–128,922,727 | 238.4 kb | Distal (>10kb) Multiome | 378 | |
| chr9:128,947,329–128,947,815 | 263.8 kb | Distal (>10kb) Multiome | 865 |
Genomic view of the SET locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.