SESN2

SESN2

sestrin 2 | DKFZp761M0212, HI95, SES2, SEST2

This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. [provided by RefSeq, Jul 2008]

Developmental clusters: GC3

Biological processes 64 terms

Atg1/ULK1 kinase complex (GO:1990316)DNA damage response, signal transduction by p53 class mediator (GO:0030330)DNA damage response, signal transduction by p53 class mediator (GO:0030330)GATOR2 complex (GO:0061700)GDP-dissociation inhibitor activity (GO:0005092)L-leucine binding (GO:0070728)L-leucine binding (GO:0070728)PH domain binding (GO:0042731)PH domain binding (GO:0042731)TORC2 complex (GO:0031932)TORC2 complex (GO:0031932)TORC2 signaling (GO:0038203)activation of protein kinase activity (GO:0032147)activation of protein kinase activity (GO:0032147)cellular oxidant detoxification (GO:0098869)cellular oxidant detoxification (GO:0098869)cellular oxidant detoxification (GO:0098869)cellular response to L-leucine (GO:0071233)cellular response to L-leucine (GO:0071233)cellular response to L-leucine (GO:0071233)cellular response to amino acid starvation (GO:0034198)cellular response to amino acid starvation (GO:0034198)cellular response to amino acid stimulus (GO:0071230)cellular response to amino acid stimulus (GO:0071230)cellular response to glucose starvation (GO:0042149)cellular response to glucose starvation (GO:0042149)cellular response to leucine starvation (GO:1990253)cellular response to leucine starvation (GO:1990253)cellular response to leucine starvation (GO:1990253)cellular response to oxidative stress (GO:0034599)cellular response to oxidative stress (GO:0034599)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)lysosomal membrane (GO:0005765)negative regulation of TORC1 signaling (GO:1904262)negative regulation of TORC1 signaling (GO:1904262)negative regulation of TORC1 signaling (GO:1904262)negative regulation of TORC1 signaling (GO:1904262)negative regulation of cell growth (GO:0030308)negative regulation of cell growth (GO:0030308)negative regulation of translation in response to endoplasmic reticulum stress (GO:1902010)negative regulation of translation in response to endoplasmic reticulum stress (GO:1902010)nucleotide-activated protein kinase complex (GO:0031588)nucleotide-activated protein kinase complex (GO:0031588)nucleus (GO:0005634)oxidoreductase activity, acting on peroxide as acceptor (GO:0016684)peroxidase activity (GO:0004601)positive regulation of TORC1 signaling (GO:1904263)positive regulation of macroautophagy (GO:0016239)positive regulation of macroautophagy (GO:0016239)positive regulation of protein localization to nucleus (GO:1900182)protein binding (GO:0005515)protein localization to plasma membrane (GO:0072659)protein sequestering activity (GO:0140311)protein-containing complex binding (GO:0044877)protein-containing complex binding (GO:0044877)reactive oxygen species metabolic process (GO:0072593)reactive oxygen species metabolic process (GO:0072593)regulation of TORC1 signaling (GO:1903432)regulation of protein phosphorylation (GO:0001932)regulation of response to reactive oxygen species (GO:1901031)sulfiredoxin activity (GO:0032542)sulfiredoxin activity (GO:0032542)

Expression (TPM)

TFs regulating SESN2 0 TFs

Transcription factors with Perturb-seq knockdown data for SESN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SESN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SESN2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SESN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chr1:27,959,376–27,960,547	299.5 kb	Distal (>10kb) Multiome	711
	chr1:28,088,113–28,088,897	170.8 kb	Distal (>10kb) Multiome	827
	chr1:28,104,959–28,105,483	154.2 kb	Distal (>10kb) Multiome	240
	chr1:28,232,593–28,233,160	26.5 kb	Distal (>10kb) Multiome	666
	chr1:28,235,692–28,236,588	23.4 kb	Distal (>10kb) Multiome	862
	chr1:28,247,126–28,247,685	12.2 kb	Distal (>10kb) Multiome	544
	chr1:28,258,840–28,260,822	901 bp	At TSS Multiome	910
	chr1:28,266,935–28,267,263	7.4 kb	Proximal (<10kb)	227
	chr1:28,369,387–28,370,499	110.3 kb	Distal (>10kb) Multiome	961
	chr1:28,505,412–28,506,885	246.4 kb	Distal (>10kb) Multiome	969
	chr1:28,513,136–28,516,505	256.0 kb	Distal (>10kb) Multiome	461
	chr1:28,517,302–28,519,364	258.8 kb	Distal (>10kb) Multiome	927
	chr1:28,552,370–28,553,806	293.5 kb	Distal (>10kb) Multiome	955

Genome Browser

Genomic view of the SESN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.