Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SERTAD4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SERTAD4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SERTAD4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:209,937,461–209,938,825 | 294.7 kb | Distal (>10kb) Multiome | 555 | |
| chr1:210,222,304–210,222,805 | 10.0 kb | Proximal (<10kb) | 193 | |
| chr1:210,232,393–210,234,634 | 50 bp | At TSS Multiome | 604 | |
| chr1:210,239,913–210,240,068 | 7.1 kb | Proximal (<10kb) | 101 | |
| chr1:210,250,530–210,250,970 | 18.0 kb | Distal (>10kb) Multiome | 203 | |
| chr1:210,251,093–210,253,535 | 18.7 kb | Distal (>10kb) Multiome | 576 | |
| chr1:210,291,920–210,292,942 | 59.7 kb | Distal (>10kb) Multiome HiCAR | 518 | |
| chr1:210,310,943–210,312,049 | 78.6 kb | Distal (>10kb) Multiome | 437 | |
| chr1:210,328,482–210,330,700 | 96.2 kb | Distal (>10kb) Multiome | 743 | |
| chr1:210,373,253–210,375,038 | 141.4 kb | Distal (>10kb) Multiome | 933 |
Genomic view of the SERTAD4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.