This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in this gene were found in individuals with osteogenesis imperfecta, type VI. [provided by RefSeq, Aug 2016]
Transcription factors with Perturb-seq knockdown data for SERPINF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SERPINF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SERPINF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:1,484,963–1,486,119 | 277.6 kb | Distal (>10kb) Multiome | 562 | |
| chr17:1,487,906–1,488,733 | 274.5 kb | Distal (>10kb) Multiome | 597 | |
| chr17:1,490,717–1,492,156 | 271.5 kb | Distal (>10kb) Multiome | 675 | |
| chr17:1,515,722–1,517,330 | 246.0 kb | Distal (>10kb) Multiome | 796 | |
| chr17:1,562,314–1,563,047 | 200.0 kb | Distal (>10kb) Multiome | 685 | |
| chr17:1,627,811–1,629,617 | 134.1 kb | Distal (>10kb) Multiome | 753 | |
| chr17:1,642,697–1,644,482 | 119.5 kb | Distal (>10kb) Multiome | 467 | |
| chr17:1,648,163–1,650,244 | 113.7 kb | Distal (>10kb) Multiome | 932 | |
| chr17:1,684,343–1,685,342 | 77.9 kb | Distal (>10kb) Multiome | 728 | |
| chr17:1,710,017–1,710,765 | 52.4 kb | Distal (>10kb) Multiome | 500 | |
| chr17:1,713,886–1,717,908 | 45.3 kb | Distal (>10kb) Multiome | 1042 | |
| chr17:1,724,373–1,725,206 | 38.1 kb | Distal (>10kb) Multiome HiCAR | 720 | |
| chr17:1,769,951–1,770,444 | 7.1 kb | Proximal (<10kb) | 439 | |
| chr17:1,829,368–1,830,287 | 67.1 kb | Distal (>10kb) Multiome | 660 | |
| chr17:1,908,573–1,908,999 | 145.8 kb | Distal (>10kb) Multiome | 239 | |
| chr17:1,997,556–1,998,757 | 235.3 kb | Distal (>10kb) Multiome | 543 | |
| chr17:2,023,483–2,024,229 | 261.0 kb | Distal (>10kb) Multiome | 281 | |
| chr17:2,024,769–2,026,284 | 262.6 kb | Distal (>10kb) Multiome | 459 | |
| chr17:2,029,741–2,030,885 | 267.2 kb | Distal (>10kb) Multiome | 871 | |
| chr17:2,041,423–2,042,366 | 279.1 kb | Distal (>10kb) Multiome | 834 | |
| chr17:2,048,764–2,051,218 | 287.4 kb | Distal (>10kb) Multiome | 658 | |
| chr17:2,053,643–2,054,179 | 290.9 kb | Distal (>10kb) Multiome | 473 | |
| chr17:2,054,616–2,055,766 | 292.3 kb | Distal (>10kb) Multiome | 544 | |
| chr17:2,058,401–2,059,503 | 296.0 kb | Distal (>10kb) Multiome | 366 |
Genomic view of the SERPINF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.