Enables several functions, including SUMO binding activity; mRNA 3'-UTR binding activity; and ribosome binding activity. Involved in PML body organization and ribosome hibernation. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SERBP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SERBP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SERBP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:67,307,261–67,308,556 | 122.5 kb | Distal (>10kb) Multiome | 323 | |
| chr1:67,392,714–67,393,694 | 37.1 kb | Distal (>10kb) Multiome | 147 | |
| chr1:67,429,433–67,431,336 | 173 bp | At TSS Multiome | 1000 | |
| chr1:67,431,841–67,431,997 | 1.4 kb | Proximal (<10kb) | 124 | |
| chr1:67,458,750–67,459,497 | 28.7 kb | Distal (>10kb) Multiome | 199 | |
| chr1:67,500,441–67,500,998 | 70.2 kb | Distal (>10kb) Multiome | 516 | |
| chr1:67,515,399–67,516,305 | 85.4 kb | Distal (>10kb) Multiome | 174 | |
| chr1:67,539,374–67,540,683 | 109.9 kb | Distal (>10kb) Multiome | 237 | |
| chr1:67,684,310–67,687,012 | 256.3 kb | Distal (>10kb) Multiome | 1205 | |
| chr1:67,688,423–67,689,311 | 258.4 kb | Distal (>10kb) Multiome | 464 |
Genomic view of the SERBP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.