Transcription factors with Perturb-seq knockdown data for SEPTIN7-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEPTIN7-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEPTIN7-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:35,537,034–35,537,920 | 263.4 kb | Distal (>10kb) Multiome | 411 | |
| chr7:35,587,467–35,588,810 | 212.9 kb | Distal (>10kb) Multiome | 70 | |
| chr7:35,624,084–35,625,028 | 176.3 kb | Distal (>10kb) Multiome | 320 | |
| chr7:35,647,096–35,647,552 | 153.7 kb | Distal (>10kb) Multiome | 270 | |
| chr7:35,694,331–35,695,753 | 105.9 kb | Distal (>10kb) Multiome | 948 | |
| chr7:35,800,074–35,802,134 | 5 bp | At TSS Multiome | 972 | |
| chr7:36,045,836–36,046,420 | 245.2 kb | Distal (>10kb) Multiome | 89 | |
| chr7:36,049,505–36,050,356 | 248.9 kb | Distal (>10kb) Multiome | 15 |
Genomic view of the SEPTIN7-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.