This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. [provided by RefSeq, Jul 2011]
Transcription factors with Perturb-seq knockdown data for SEPTIN7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEPTIN7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEPTIN7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:35,537,034–35,537,920 | 263.6 kb | Distal (>10kb) Multiome | 411 | |
| chr7:35,587,467–35,588,810 | 213.1 kb | Distal (>10kb) Multiome | 70 | |
| chr7:35,624,084–35,625,028 | 176.5 kb | Distal (>10kb) Multiome | 320 | |
| chr7:35,647,096–35,647,552 | 153.9 kb | Distal (>10kb) Multiome | 270 | |
| chr7:35,694,331–35,695,753 | 106.1 kb | Distal (>10kb) Multiome | 948 | |
| chr7:35,800,074–35,802,134 | 231 bp | At TSS Multiome | 972 | |
| chr7:36,045,836–36,046,420 | 245.0 kb | Distal (>10kb) Multiome | 89 | |
| chr7:36,049,505–36,050,356 | 248.7 kb | Distal (>10kb) Multiome | 15 | |
| chr7:36,084,466–36,085,311 | 283.6 kb | Distal (>10kb) Multiome | 475 |
Genomic view of the SEPTIN7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.