This gene belongs to the septin family of GTPases. Members of this family are required for cytokinesis. Expression is upregulated by retinoic acid in a human teratocarcinoma cell line. The specific function of this gene has not been determined. Alternative splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, May 2018]
Transcription factors with Perturb-seq knockdown data for SEPTIN3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEPTIN3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEPTIN3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:41,697,169–41,697,792 | 279.5 kb | Distal (>10kb) Multiome | 464 | |
| chr22:41,800,274–41,801,345 | 176.2 kb | Distal (>10kb) Multiome | 816 | |
| chr22:41,832,291–41,834,215 | 143.9 kb | Distal (>10kb) Multiome | 1023 | |
| chr22:41,909,821–41,910,788 | 66.6 kb | Distal (>10kb) Multiome | 251 | |
| chr22:41,913,915–41,914,497 | 62.7 kb | Distal (>10kb) Multiome | 143 | |
| chr22:41,914,624–41,915,454 | 61.7 kb | Distal (>10kb) Multiome | 273 | |
| chr22:41,919,501–41,920,436 | 56.8 kb | Distal (>10kb) Multiome | 337 | |
| chr22:41,926,076–41,926,820 | 50.6 kb | Distal (>10kb) Multiome | 442 | |
| chr22:41,945,821–41,947,304 | 29.9 kb | Distal (>10kb) Multiome | 896 | |
| chr22:41,957,553–41,958,332 | 19.0 kb | Distal (>10kb) Multiome | 456 | |
| chr22:41,966,776–41,967,257 | 9.6 kb | Proximal (<10kb) | 152 | |
| chr22:41,976,503–41,977,084 | 14 bp | At TSS Multiome | 294 | |
| chr22:42,070,303–42,071,253 | 94.0 kb | Distal (>10kb) Multiome | 833 | |
| chr22:42,074,171–42,074,703 | 97.5 kb | Distal (>10kb) Multiome | 178 | |
| chr22:42,079,194–42,080,293 | 102.9 kb | Distal (>10kb) Multiome | 872 | |
| chr22:42,090,032–42,091,609 | 114.1 kb | Distal (>10kb) Multiome | 910 | |
| chr22:42,269,385–42,271,172 | 292.7 kb | Distal (>10kb) Multiome | 751 |
Genomic view of the SEPTIN3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.