Enables identical protein binding activity. Predicted to be involved in several processes, including cilium assembly; cytoskeleton-dependent cytokinesis; and smoothened signaling pathway. Predicted to act upstream of or within regulation of L-glutamate import across plasma membrane and regulation of protein localization. Located in several cellular components, including cytoskeleton; photoreceptor connecting cilium; and sperm annulus. Part of septin complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SEPTIN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEPTIN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEPTIN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:241,102,057–241,102,727 | 213.5 kb | Distal (>10kb) Multiome | 1072 | |
| chr2:241,148,805–241,150,972 | 166.5 kb | Distal (>10kb) Multiome | 897 | |
| chr2:241,217,134–241,217,954 | 98.2 kb | Distal (>10kb) Multiome | 700 | |
| chr2:241,272,147–241,273,188 | 43.1 kb | Distal (>10kb) Multiome | 539 | |
| chr2:241,314,756–241,316,790 | 410 bp | At TSS Multiome | 1143 | |
| chr2:241,354,545–241,355,644 | 39.1 kb | Distal (>10kb) Multiome | 625 | |
| chr2:241,355,946–241,356,875 | 40.3 kb | Distal (>10kb) Multiome | 680 | |
| chr2:241,507,257–241,509,444 | 192.8 kb | Distal (>10kb) Multiome | 1050 | |
| chr2:241,540,846–241,542,485 | 225.4 kb | Distal (>10kb) Multiome | 394 | |
| chr2:241,558,542–241,559,899 | 242.9 kb | Distal (>10kb) Multiome | 638 | |
| chr2:241,609,833–241,610,860 | 294.5 kb | Distal (>10kb) Multiome | 755 |
Genomic view of the SEPTIN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.