This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for SEMA7A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEMA7A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEMA7A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:74,134,110–74,134,917 | 299.4 kb | Distal (>10kb) Multiome | 220 | |
| chr15:74,135,992–74,136,743 | 297.6 kb | Distal (>10kb) Multiome | 439 | |
| chr15:74,202,453–74,203,387 | 231.1 kb | Distal (>10kb) Multiome | 381 | |
| chr15:74,208,748–74,209,470 | 224.8 kb | Distal (>10kb) Multiome | 233 | |
| chr15:74,291,174–74,291,950 | 142.4 kb | Distal (>10kb) Multiome | 773 | |
| chr15:74,365,599–74,366,233 | 68.0 kb | Distal (>10kb) Multiome | 441 | |
| chr15:74,373,469–74,375,034 | 59.5 kb | Distal (>10kb) Multiome HiCAR | 745 | |
| chr15:74,433,053–74,434,500 | 27 bp | At TSS Multiome | 695 | |
| chr15:74,438,775–74,438,995 | 4.8 kb | Proximal (<10kb) | 322 | |
| chr15:74,442,747–74,443,026 | 8.8 kb | Proximal (<10kb) | 172 | |
| chr15:74,443,466–74,443,886 | 9.5 kb | Proximal (<10kb) | 342 | |
| chr15:74,460,798–74,461,761 | 27.3 kb | Distal (>10kb) Multiome | 925 | |
| chr15:74,531,382–74,531,884 | 97.7 kb | Distal (>10kb) Multiome | 217 | |
| chr15:74,540,389–74,542,119 | 107.2 kb | Distal (>10kb) Multiome | 838 | |
| chr15:74,598,102–74,598,966 | 164.5 kb | Distal (>10kb) Multiome | 689 | |
| chr15:74,614,343–74,616,348 | 181.8 kb | Distal (>10kb) Multiome | 1019 | |
| chr15:74,695,758–74,696,387 | 262.1 kb | Distal (>10kb) Multiome | 775 | |
| chr15:74,725,773–74,726,537 | 292.2 kb | Distal (>10kb) Multiome | 607 |
Genomic view of the SEMA7A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.