This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is specifically expressed in the testis. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2017]
Transcription factors with Perturb-seq knockdown data for SELENOV. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SELENOV upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SELENOV, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:39,307,021–39,308,955 | 207.9 kb | Distal (>10kb) Multiome | 358 | |
| chr19:39,320,514–39,321,175 | 194.6 kb | Distal (>10kb) Multiome | 364 | |
| chr19:39,341,491–39,342,890 | 173.2 kb | Distal (>10kb) Multiome | 934 | |
| chr19:39,390,544–39,391,970 | 124.3 kb | Distal (>10kb) Multiome | 1003 | |
| chr19:39,397,520–39,398,126 | 117.6 kb | Distal (>10kb) Multiome | 711 | |
| chr19:39,402,336–39,404,125 | 111.5 kb | Distal (>10kb) Multiome | 826 | |
| chr19:39,406,270–39,408,010 | 108.7 kb | Distal (>10kb) Multiome | 804 | |
| chr19:39,409,417–39,410,433 | 105.7 kb | Distal (>10kb) Multiome | 884 | |
| chr19:39,411,293–39,414,170 | 103.0 kb | Distal (>10kb) Multiome | 1109 | |
| chr19:39,428,269–39,428,993 | 86.8 kb | Distal (>10kb) Multiome | 479 | |
| chr19:39,435,526–39,436,258 | 79.4 kb | Distal (>10kb) Multiome | 930 | |
| chr19:39,445,191–39,446,019 | 69.9 kb | Distal (>10kb) Multiome | 927 | |
| chr19:39,480,241–39,481,284 | 34.7 kb | Distal (>10kb) Multiome | 880 | |
| chr19:39,497,736–39,498,430 | 17.4 kb | Distal (>10kb) Multiome | 558 | |
| chr19:39,502,647–39,503,265 | 12.5 kb | Distal (>10kb) Multiome | 835 | |
| chr19:39,506,926–39,507,691 | 8.2 kb | Proximal (<10kb) Multiome | 748 | |
| chr19:39,514,761–39,515,964 | 152 bp | At TSS Multiome | 370 | |
| chr19:39,532,304–39,533,247 | 17.4 kb | Distal (>10kb) Multiome | 760 | |
| chr19:39,539,469–39,540,414 | 24.7 kb | Distal (>10kb) Multiome | 772 | |
| chr19:39,793,033–39,793,501 | 277.8 kb | Distal (>10kb) Multiome | 418 |
Genomic view of the SELENOV locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.