This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019). [provided by RefSeq, Jul 2017]
Transcription factors with Perturb-seq knockdown data for SELENOS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SELENOS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SELENOS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:101,008,268–101,008,757 | 268.9 kb | Distal (>10kb) Multiome | 571 | |
| chr15:101,068,707–101,069,646 | 208.2 kb | Distal (>10kb) Multiome | 435 | |
| chr15:101,077,927–101,078,550 | 199.3 kb | Distal (>10kb) Multiome | 35 | |
| chr15:101,088,678–101,089,262 | 188.5 kb | Distal (>10kb) Multiome | 541 | |
| chr15:101,201,405–101,201,942 | 75.9 kb | Distal (>10kb) Multiome | 276 | |
| chr15:101,250,886–101,252,530 | 25.5 kb | Distal (>10kb) Multiome | 729 | |
| chr15:101,267,074–101,267,634 | 9.8 kb | Proximal (<10kb) | 97 | |
| chr15:101,276,817–101,277,913 | 19 bp | At TSS Multiome | 748 | |
| chr15:101,280,001–101,280,817 | 2.5 kb | Proximal (<10kb) | 60 | |
| chr15:101,294,732–101,295,714 | 17.8 kb | Distal (>10kb) Multiome | 987 | |
| chr15:101,489,250–101,490,332 | 212.2 kb | Distal (>10kb) Multiome | 422 |
Genomic view of the SELENOS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.