The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Dec 2016]
Transcription factors with Perturb-seq knockdown data for SELENOM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SELENOM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SELENOM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:30,968,406–30,969,906 | 138.4 kb | Distal (>10kb) Multiome | 897 | |
| chr22:31,080,687–31,081,783 | 26.4 kb | Distal (>10kb) Multiome | 636 | |
| chr22:31,084,596–31,085,743 | 22.5 kb | Distal (>10kb) Multiome | 448 | |
| chr22:31,098,574–31,099,237 | 8.7 kb | Proximal (<10kb) Multiome | 150 | |
| chr22:31,104,824–31,105,447 | 2.5 kb | Proximal (<10kb) Multiome | 187 | |
| chr22:31,107,269–31,107,915 | 97 bp | At TSS Multiome | 627 | |
| chr22:31,127,262–31,127,766 | 20.0 kb | Distal (>10kb) Multiome | 74 | |
| chr22:31,140,179–31,140,721 | 33.0 kb | Distal (>10kb) Multiome | 244 | |
| chr22:31,160,052–31,160,698 | 52.7 kb | Distal (>10kb) Multiome | 709 | |
| chr22:31,211,835–31,212,727 | 104.6 kb | Distal (>10kb) Multiome | 769 | |
| chr22:31,290,525–31,291,372 | 183.3 kb | Distal (>10kb) Multiome | 818 | |
| chr22:31,345,143–31,347,910 | 238.5 kb | Distal (>10kb) Multiome | 954 | |
| chr22:31,362,564–31,363,231 | 255.3 kb | Distal (>10kb) Multiome | 164 | |
| chr22:31,399,166–31,400,036 | 291.9 kb | Distal (>10kb) Multiome | 913 |
Genomic view of the SELENOM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.