The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Pseudogenes of this locus have been identified on chromosomes 6 and 19.[provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for SELENOK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SELENOK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SELENOK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:53,842,545–53,843,152 | 49.1 kb | Distal (>10kb) Multiome | 473 | |
| chr3:53,845,424–53,846,842 | 45.5 kb | Distal (>10kb) Multiome | 849 | |
| chr3:53,881,538–53,882,565 | 9.8 kb | Proximal (<10kb) Multiome | 818 | |
| chr3:53,891,162–53,892,300 | 110 bp | At TSS Multiome | 760 | |
| chr3:53,938,728–53,939,694 | 47.3 kb | Distal (>10kb) Multiome | 239 | |
| chr3:54,087,508–54,088,258 | 196.0 kb | Distal (>10kb) Multiome | 177 | |
| chr3:54,120,980–54,123,073 | 230.3 kb | Distal (>10kb) Multiome | 295 |
Genomic view of the SELENOK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.