The protein encoded by this gene is part of a nuclear pore complex, Nup107-160. This protein contains WD repeats and shares 34% amino acid identity with yeast Seh1 and 30% identity with yeast Sec13. All constituents of the Nup107-160 complex, including this protein, specifically localize to kinetochores in mitosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SEH1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEH1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEH1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:12,657,070–12,658,817 | 289.9 kb | Distal (>10kb) Multiome | 689 | |
| chr18:12,702,219–12,703,287 | 245.2 kb | Distal (>10kb) Multiome | 869 | |
| chr18:12,766,645–12,767,371 | 180.8 kb | Distal (>10kb) Multiome | 392 | |
| chr18:12,776,564–12,778,096 | 170.9 kb | Distal (>10kb) Multiome | 123 | |
| chr18:12,862,247–12,862,768 | 85.4 kb | Distal (>10kb) Multiome | 116 | |
| chr18:12,883,233–12,884,627 | 63.8 kb | Distal (>10kb) Multiome | 904 | |
| chr18:12,937,889–12,938,103 | 9.9 kb | Proximal (<10kb) | 12 | |
| chr18:12,946,945–12,948,745 | 44 bp | At TSS Multiome | 1139 | |
| chr18:12,989,036–12,990,533 | 41.5 kb | Distal (>10kb) Multiome | 336 | |
| chr18:12,990,680–12,991,971 | 43.3 kb | Distal (>10kb) Multiome | 977 | |
| chr18:13,003,392–13,003,928 | 55.6 kb | Distal (>10kb) Multiome | 168 | |
| chr18:13,216,871–13,219,231 | 269.5 kb | Distal (>10kb) Multiome | 503 |
Genomic view of the SEH1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.