Enables RNA binding activity. Predicted to be part of ribonucleoprotein complex. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SECISBP2L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SECISBP2L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SECISBP2L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:48,810,417–48,812,023 | 235.3 kb | Distal (>10kb) Multiome | 720 | |
| chr15:48,877,739–48,878,642 | 168.3 kb | Distal (>10kb) Multiome | 662 | |
| chr15:48,962,833–48,964,051 | 82.9 kb | Distal (>10kb) Multiome | 430 | |
| chr15:48,975,511–48,976,786 | 70.5 kb | Distal (>10kb) Multiome | 622 | |
| chr15:49,045,768–49,047,113 | 80 bp | At TSS Multiome | 979 | |
| chr15:49,154,953–49,156,105 | 109.2 kb | Distal (>10kb) Multiome | 952 | |
| chr15:49,169,904–49,170,701 | 123.8 kb | Distal (>10kb) Multiome | 762 | |
| chr15:49,225,493–49,226,165 | 179.4 kb | Distal (>10kb) Multiome | 183 |
Genomic view of the SECISBP2L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.