The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SEC63. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEC63 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEC63, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:107,675,165–107,675,837 | 282.6 kb | Distal (>10kb) Multiome | 556 | |
| chr6:107,847,911–107,848,803 | 109.7 kb | Distal (>10kb) Multiome | 650 | |
| chr6:107,957,316–107,958,729 | 179 bp | At TSS Multiome | 909 | |
| chr6:108,074,193–108,075,197 | 116.7 kb | Distal (>10kb) Multiome | 935 | |
| chr6:108,117,713–108,118,288 | 159.9 kb | Distal (>10kb) Multiome | 242 | |
| chr6:108,133,646–108,134,560 | 175.9 kb | Distal (>10kb) Multiome | 560 | |
| chr6:108,164,692–108,165,502 | 207.0 kb | Distal (>10kb) Multiome | 111 |
Genomic view of the SEC63 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.