SEC31B

SEC31 homolog B, COPII component | DKFZP434M183, SEC31B-1, SEC31L2

This gene encodes a protein of unknown function. The protein has moderate similarity to rat VAP1 protein which is an endosomal membrane-associated protein, containing a putative Ca2+/calmodulin-dependent kinase II phosphorylation site. [provided by RefSeq, Jul 2008]

Biological processes 15 terms

COPII vesicle coat (GO:0030127)COPII-coated vesicle cargo loading (GO:0090110)ER to Golgi transport vesicle membrane (GO:0012507)cytoplasm (GO:0005737)cytosol (GO:0005829)endoplasmic reticulum (GO:0005783)endoplasmic reticulum exit site (GO:0070971)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum organization (GO:0007029)endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888)positive regulation of ER to Golgi vesicle-mediated transport (GO:1902953)positive regulation of protein exit from endoplasmic reticulum (GO:0070863)structural molecule activity (GO:0005198)vesicle coat (GO:0030120)vesicle coat (GO:0030120)

Expression (TPM)

TFs regulating SEC31B 0 TFs

Transcription factors with Perturb-seq knockdown data for SEC31B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEC31B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SEC31B

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEC31B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr10:100,228,957–100,229,948	290.3 kb	Distal (>10kb) Multiome	759
chr10:100,267,386–100,267,986	252.1 kb	Distal (>10kb) Multiome	715
chr10:100,286,018–100,287,021	233.3 kb	Distal (>10kb) Multiome	849
chr10:100,346,401–100,347,640	173.0 kb	Distal (>10kb) Multiome HiCAR	919
chr10:100,359,067–100,359,724	160.6 kb	Distal (>10kb) Multiome	425
chr10:100,372,854–100,374,386	146.3 kb	Distal (>10kb) Multiome	964
chr10:100,481,576–100,482,049	38.2 kb	Distal (>10kb) Multiome	298
chr10:100,482,268–100,483,078	37.0 kb	Distal (>10kb) Multiome	497
chr10:100,485,778–100,486,586	33.7 kb	Distal (>10kb) Multiome	161
chr10:100,518,832–100,519,948	405 bp	At TSS Multiome	417
chr10:100,529,444–100,530,236	10.0 kb	Distal (>10kb) Multiome	619
chr10:100,535,502–100,536,234	16.1 kb	Distal (>10kb) Multiome	759
chr10:100,561,994–100,562,629	42.3 kb	Distal (>10kb) Multiome	491
chr10:100,654,597–100,655,452	135.3 kb	Distal (>10kb) Multiome	300
chr10:100,656,014–100,657,003	136.9 kb	Distal (>10kb) Multiome	310
chr10:100,670,865–100,671,507	151.3 kb	Distal (>10kb) Multiome	364
chr10:100,680,805–100,681,542	161.2 kb	Distal (>10kb) Multiome	636
chr10:100,729,074–100,730,178	209.6 kb	Distal (>10kb) Multiome	304
chr10:100,739,174–100,740,373	219.9 kb	Distal (>10kb) Multiome	205
chr10:100,744,447–100,746,357	225.6 kb	Distal (>10kb) Multiome	379
chr10:100,760,518–100,761,080	241.0 kb	Distal (>10kb) Multiome	105
chr10:100,787,902–100,788,519	268.4 kb	Distal (>10kb) Multiome	52

Genome Browser

Genomic view of the SEC31B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.