The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SEC23A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEC23A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEC23A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:39,102,463–39,103,834 | 57 bp | At TSS Multiome | 1067 | |
| chr14:39,112,760–39,113,146 | 9.5 kb | Proximal (<10kb) | 7 | |
| chr14:39,114,070–39,114,631 | 11.1 kb | Distal (>10kb) Multiome | 834 | |
| chr14:39,169,826–39,170,847 | 67.2 kb | Distal (>10kb) Multiome | 1008 | |
| chr14:39,174,486–39,175,885 | 71.9 kb | Distal (>10kb) Multiome | 1141 | |
| chr14:39,203,536–39,204,758 | 100.9 kb | Distal (>10kb) Multiome | 293 | |
| chr14:39,266,213–39,267,903 | 164.0 kb | Distal (>10kb) Multiome | 1124 |
Genomic view of the SEC23A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.