This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2013]
Transcription factors with Perturb-seq knockdown data for SDHC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SDHC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SDHC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:161,020,536–161,021,920 | 293.1 kb | Distal (>10kb) Multiome | 846 | |
| chr1:161,038,489–161,039,130 | 275.4 kb | Distal (>10kb) Multiome | 468 | |
| chr1:161,045,080–161,046,516 | 268.4 kb | Distal (>10kb) Multiome | 927 | |
| chr1:161,097,691–161,099,047 | 216.1 kb | Distal (>10kb) Multiome | 829 | |
| chr1:161,117,504–161,118,419 | 196.3 kb | Distal (>10kb) Multiome | 794 | |
| chr1:161,131,760–161,133,351 | 181.7 kb | Distal (>10kb) Multiome | 956 | |
| chr1:161,153,700–161,154,461 | 160.4 kb | Distal (>10kb) Multiome | 816 | |
| chr1:161,158,928–161,160,167 | 154.9 kb | Distal (>10kb) Multiome | 706 | |
| chr1:161,165,740–161,167,170 | 148.0 kb | Distal (>10kb) Multiome | 888 | |
| chr1:161,176,874–161,177,972 | 136.9 kb | Distal (>10kb) Multiome | 910 | |
| chr1:161,198,215–161,199,209 | 115.8 kb | Distal (>10kb) Multiome HiCAR | 357 | |
| chr1:161,201,572–161,202,783 | 112.1 kb | Distal (>10kb) Multiome HiCAR | 852 | |
| chr1:161,225,326–161,226,910 | 88.5 kb | Distal (>10kb) Multiome HiCAR | 710 | |
| chr1:161,227,235–161,227,802 | 86.9 kb | Distal (>10kb) Multiome | 372 | |
| chr1:161,258,515–161,259,098 | 55.6 kb | Distal (>10kb) Multiome | 281 | |
| chr1:161,305,737–161,306,708 | 8.1 kb | Proximal (<10kb) Multiome | 430 | |
| chr1:161,313,977–161,314,703 | 41 bp | At TSS Multiome | 824 | |
| chr1:161,314,793–161,314,971 | 406 bp | At TSS | 352 | |
| chr1:161,316,078–161,316,562 | 1.7 kb | Proximal (<10kb) | 59 | |
| chr1:161,389,675–161,390,784 | 75.7 kb | Distal (>10kb) Multiome | 866 | |
| chr1:161,399,098–161,400,259 | 85.3 kb | Distal (>10kb) Multiome | 1040 | |
| chr1:161,523,599–161,524,629 | 209.7 kb | Distal (>10kb) Multiome | 513 | |
| chr1:161,530,606–161,531,531 | 216.6 kb | Distal (>10kb) Multiome | 645 | |
| chr1:161,539,909–161,540,503 | 225.9 kb | Distal (>10kb) Multiome | 653 | |
| chr1:161,612,174–161,612,901 | 298.1 kb | Distal (>10kb) Multiome | 601 |
Genomic view of the SDHC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.