Predicted to be involved in mitochondrial respiratory chain complex II assembly; regulation of gluconeogenesis; and succinate metabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SDHAF3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SDHAF3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SDHAF3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:96,992,387–96,993,486 | 124.4 kb | Distal (>10kb) Multiome | 216 | |
| chr7:97,001,603–97,002,708 | 115.6 kb | Distal (>10kb) Multiome | 161 | |
| chr7:97,005,154–97,007,514 | 112.3 kb | Distal (>10kb) Multiome | 699 | |
| chr7:97,016,407–97,017,582 | 100.9 kb | Distal (>10kb) Multiome | 599 | |
| chr7:97,020,725–97,022,291 | 96.3 kb | Distal (>10kb) Multiome | 217 | |
| chr7:97,023,662–97,025,361 | 93.1 kb | Distal (>10kb) Multiome | 445 | |
| chr7:97,117,080–97,118,202 | 80 bp | At TSS Multiome | 965 | |
| chr7:97,126,320–97,126,801 | 8.6 kb | Proximal (<10kb) | 147 | |
| chr7:97,871,662–97,873,006 | 754.7 kb | Distal (>10kb) Multiome HiCAR | 963 | |
| chr7:97,927,848–97,928,741 | 810.7 kb | Distal (>10kb) Multiome HiCAR | 142 |
Genomic view of the SDHAF3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.