Enables misfolded protein binding activity. Involved in chaperone cofactor-dependent protein refolding. Located in endoplasmic reticulum. Part of protein folding chaperone complex. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for SDF2L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SDF2L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SDF2L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:21,567,510–21,568,436 | 74.6 kb | Distal (>10kb) Multiome HiCAR | 951 | |
| chr22:21,628,821–21,630,259 | 12.2 kb | Distal (>10kb) Multiome | 1055 | |
| chr22:21,641,511–21,643,313 | 146 bp | At TSS Multiome | 754 | |
| chr22:21,650,780–21,651,192 | 8.5 kb | Proximal (<10kb) | 111 | |
| chr22:21,651,622–21,652,445 | 9.8 kb | Proximal (<10kb) Multiome | 719 | |
| chr22:21,657,073–21,658,429 | 15.3 kb | Distal (>10kb) Multiome | 802 | |
| chr22:21,665,721–21,666,577 | 23.8 kb | Distal (>10kb) Multiome | 893 | |
| chr22:21,735,345–21,736,601 | 93.7 kb | Distal (>10kb) Multiome | 774 | |
| chr22:21,864,937–21,865,391 | 222.8 kb | Distal (>10kb) Multiome | 184 | |
| chr22:21,866,936–21,868,402 | 225.5 kb | Distal (>10kb) Multiome | 929 | |
| chr22:21,925,450–21,926,079 | 283.5 kb | Distal (>10kb) Multiome | 169 | |
| chr22:21,938,040–21,938,786 | 296.0 kb | Distal (>10kb) Multiome | 871 |
Genomic view of the SDF2L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.