The protein encoded by this gene is believed to be a secretory protein. It has regions of similarity to hydrophilic segments of yeast mannosyltransferases. Its expression is ubiquitous and the gene appears to be relatively conserved among mammals. Alternate splicing results in both coding and non-coding variants. A pseudogene of this gene is located on chromosome 15. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for SDF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SDF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SDF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:28,371,118–28,372,519 | 290.4 kb | Distal (>10kb) Multiome | 532 | |
| chr17:28,381,316–28,381,844 | 280.3 kb | Distal (>10kb) Multiome | 159 | |
| chr17:28,405,673–28,406,384 | 255.9 kb | Distal (>10kb) Multiome | 591 | |
| chr17:28,466,531–28,467,034 | 195.1 kb | Distal (>10kb) Multiome | 179 | |
| chr17:28,551,965–28,553,140 | 109.3 kb | Distal (>10kb) Multiome | 557 | |
| chr17:28,570,861–28,571,983 | 90.3 kb | Distal (>10kb) Multiome | 701 | |
| chr17:28,576,649–28,577,524 | 84.9 kb | Distal (>10kb) Multiome | 652 | |
| chr17:28,598,491–28,599,842 | 62.8 kb | Distal (>10kb) Multiome | 810 | |
| chr17:28,621,936–28,622,562 | 39.6 kb | Distal (>10kb) Multiome | 55 | |
| chr17:28,644,541–28,645,596 | 16.7 kb | Distal (>10kb) Multiome | 795 | |
| chr17:28,661,635–28,662,527 | 218 bp | At TSS Multiome | 809 | |
| chr17:28,710,720–28,712,813 | 49.5 kb | Distal (>10kb) Multiome | 892 | |
| chr17:28,717,030–28,718,784 | 56.0 kb | Distal (>10kb) Multiome | 492 | |
| chr17:28,718,918–28,720,313 | 57.9 kb | Distal (>10kb) Multiome | 927 | |
| chr17:28,724,652–28,729,474 | 65.1 kb | Distal (>10kb) Multiome | 1286 | |
| chr17:28,743,083–28,744,926 | 82.2 kb | Distal (>10kb) Multiome | 991 | |
| chr17:28,745,076–28,746,436 | 83.7 kb | Distal (>10kb) Multiome | 568 | |
| chr17:28,749,859–28,750,549 | 88.3 kb | Distal (>10kb) Multiome | 550 | |
| chr17:28,811,615–28,812,945 | 150.6 kb | Distal (>10kb) Multiome | 699 | |
| chr17:28,842,307–28,843,098 | 180.9 kb | Distal (>10kb) Multiome | 717 | |
| chr17:28,854,460–28,855,289 | 193.0 kb | Distal (>10kb) Multiome | 780 | |
| chr17:28,896,962–28,898,028 | 235.7 kb | Distal (>10kb) Multiome | 846 | |
| chr17:28,902,302–28,903,488 | 241.1 kb | Distal (>10kb) Multiome | 967 | |
| chr17:28,950,281–28,952,708 | 289.8 kb | Distal (>10kb) Multiome | 989 |
Genomic view of the SDF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.