The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SDC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SDC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SDC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:19,989,520–19,990,653 | 235.3 kb | Distal (>10kb) Multiome | 924 | |
| chr2:20,011,873–20,013,148 | 212.8 kb | Distal (>10kb) Multiome | 585 | |
| chr2:20,050,661–20,052,578 | 173.5 kb | Distal (>10kb) Multiome | 1029 | |
| chr2:20,097,914–20,098,555 | 127.1 kb | Distal (>10kb) Multiome | 480 | |
| chr2:20,106,361–20,107,468 | 118.5 kb | Distal (>10kb) Multiome | 181 | |
| chr2:20,223,290–20,226,136 | 1.8 kb | Proximal (<10kb) Multiome | 1023 | |
| chr2:20,231,345–20,232,291 | 5.9 kb | Proximal (<10kb) | 358 | |
| chr2:20,242,059–20,243,494 | 17.0 kb | Distal (>10kb) Multiome | 372 | |
| chr2:20,350,092–20,352,594 | 125.4 kb | Distal (>10kb) Multiome | 1127 | |
| chr2:20,446,303–20,448,812 | 221.6 kb | Distal (>10kb) Multiome | 1072 | |
| chr2:20,510,011–20,510,507 | 284.8 kb | Distal (>10kb) Multiome | 307 |
Genomic view of the SDC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.