This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SCYL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCYL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCYL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:65,225,439–65,226,037 | 299.5 kb | Distal (>10kb) Multiome | 522 | |
| chr11:65,261,186–65,262,526 | 263.3 kb | Distal (>10kb) Multiome | 777 | |
| chr11:65,314,302–65,316,053 | 209.4 kb | Distal (>10kb) Multiome | 803 | |
| chr11:65,333,360–65,334,372 | 191.3 kb | Distal (>10kb) Multiome | 654 | |
| chr11:65,354,023–65,355,987 | 170.5 kb | Distal (>10kb) Multiome HiCAR | 677 | |
| chr11:65,366,306–65,366,977 | 158.5 kb | Distal (>10kb) Multiome HiCAR | 309 | |
| chr11:65,381,835–65,382,758 | 142.9 kb | Distal (>10kb) Multiome HiCAR | 984 | |
| chr11:65,386,320–65,387,097 | 138.5 kb | Distal (>10kb) Multiome HiCAR | 757 | |
| chr11:65,416,383–65,417,015 | 108.6 kb | Distal (>10kb) Multiome | 664 | |
| chr11:65,417,855–65,419,687 | 106.0 kb | Distal (>10kb) Multiome | 1018 | |
| chr11:65,421,858–65,423,533 | 102.7 kb | Distal (>10kb) Multiome | 1197 | |
| chr11:65,454,735–65,455,360 | 69.9 kb | Distal (>10kb) Multiome | 573 | |
| chr11:65,477,100–65,477,990 | 47.5 kb | Distal (>10kb) Multiome | 991 | |
| chr11:65,487,451–65,488,490 | 37.3 kb | Distal (>10kb) Multiome | 706 | |
| chr11:65,496,515–65,498,726 | 27.5 kb | Distal (>10kb) Multiome | 1059 | |
| chr11:65,506,702–65,508,865 | 17.9 kb | Distal (>10kb) Multiome | 864 | |
| chr11:65,524,475–65,525,724 | 103 bp | At TSS Multiome | 711 | |
| chr11:65,538,923–65,541,339 | 15.7 kb | Distal (>10kb) Multiome | 733 | |
| chr11:65,546,285–65,547,091 | 21.6 kb | Distal (>10kb) Multiome | 529 | |
| chr11:65,553,318–65,554,003 | 28.6 kb | Distal (>10kb) Multiome | 195 | |
| chr11:65,569,718–65,570,745 | 45.2 kb | Distal (>10kb) Multiome | 930 | |
| chr11:65,571,973–65,573,008 | 47.4 kb | Distal (>10kb) Multiome | 420 | |
| chr11:65,573,788–65,575,269 | 49.2 kb | Distal (>10kb) Multiome | 742 | |
| chr11:65,575,601–65,576,322 | 50.9 kb | Distal (>10kb) Multiome | 527 | |
| chr11:65,591,808–65,592,698 | 67.1 kb | Distal (>10kb) Multiome | 169 | |
| chr11:65,606,536–65,607,917 | 82.1 kb | Distal (>10kb) Multiome | 376 | |
| chr11:65,613,478–65,614,645 | 89.1 kb | Distal (>10kb) Multiome | 702 | |
| chr11:65,614,954–65,616,793 | 90.4 kb | Distal (>10kb) Multiome | 830 | |
| chr11:65,637,768–65,638,920 | 113.0 kb | Distal (>10kb) Multiome | 740 | |
| chr11:65,641,918–65,642,633 | 117.1 kb | Distal (>10kb) Multiome | 155 | |
| chr11:65,646,814–65,647,818 | 122.2 kb | Distal (>10kb) Multiome | 270 | |
| chr11:65,652,106–65,653,317 | 127.6 kb | Distal (>10kb) Multiome | 901 | |
| chr11:65,662,517–65,663,930 | 137.9 kb | Distal (>10kb) Multiome | 839 | |
| chr11:65,711,437–65,712,942 | 187.2 kb | Distal (>10kb) Multiome | 1143 | |
| chr11:65,720,215–65,720,955 | 195.6 kb | Distal (>10kb) Multiome | 821 | |
| chr11:65,779,808–65,781,988 | 255.0 kb | Distal (>10kb) Multiome | 764 | |
| chr11:65,785,898–65,789,101 | 263.3 kb | Distal (>10kb) Multiome | 478 | |
| chr11:65,817,968–65,818,502 | 293.1 kb | Distal (>10kb) Multiome | 694 |
Genomic view of the SCYL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.