SCT
secretin

This gene encodes a member of the glucagon family of peptides. The encoded preproprotein is secreted by endocrine S cells in the proximal small intestinal mucosa as a prohormone, then proteolytically processed to generate the mature peptide hormone. The release of this active peptide hormone is stimulated by either fatty acids or acidic pH in the duodenum. This hormone stimulates the secretion of bile and bicarbonate in the duodenum, pancreatic and biliary ducts. [provided by RefSeq, Feb 2016]

Biological processes 38 terms
G protein-coupled receptor binding (GO:0001664)adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0007189)adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0007189)brain development (GO:0007420)diet induced thermogenesis (GO:0002024)diet induced thermogenesis (GO:0002024)digestive hormone activity (GO:0046659)digestive hormone activity (GO:0046659)embryonic digestive tract development (GO:0048566)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)hippocampus development (GO:0021766)hippocampus development (GO:0021766)hormone activity (GO:0005179)hormone activity (GO:0005179)hormone activity (GO:0005179)intracellular water homeostasis (GO:0009992)intracellular water homeostasis (GO:0009992)negative regulation of gastrin-induced gastric acid secretion (GO:1903640)negative regulation of gastrin-induced gastric acid secretion (GO:1903640)pancreatic juice secretion (GO:0030157)positive regulation of cAMP/PKA signal transduction (GO:0141163)positive regulation of lipid catabolic process (GO:0050996)positive regulation of lipid catabolic process (GO:0050996)positive regulation of pancreatic juice secretion (GO:0090187)positive regulation of pancreatic juice secretion (GO:0090187)positive regulation of somatostatin secretion (GO:0090274)positive regulation of somatostatin secretion (GO:0090274)protein binding (GO:0005515)regulation of appetite (GO:0032098)regulation of appetite (GO:0032098)regulation of synaptic plasticity (GO:0048167)regulation of synaptic plasticity (GO:0048167)response to nutrient levels (GO:0031667)response to nutrient levels (GO:0031667)signaling receptor binding (GO:0005102)
Expression (TPM)
SCT — as a Regulated Gene

TFs regulating SCT 0 TFs

Transcription factors with Perturb-seq knockdown data for SCT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to SCT

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr11:333,722–334,610 292.9 kb Distal (>10kb) Multiome 238
chr11:355,654–356,479 271.0 kb Distal (>10kb) Multiome 894
chr11:370,037–370,556 257.0 kb Distal (>10kb) Multiome 205
chr11:406,008–408,661 219.9 kb Distal (>10kb) Multiome 587
chr11:416,764–417,613 209.8 kb Distal (>10kb) Multiome 431
chr11:447,919–448,752 178.9 kb Distal (>10kb) Multiome 808
chr11:449,838–451,194 176.9 kb Distal (>10kb) Multiome 836
chr11:506,153–507,989 120.0 kb Distal (>10kb) Multiome 977
chr11:534,525–536,399 91.5 kb Distal (>10kb) Multiome 673
chr11:536,654–537,918 89.7 kb Distal (>10kb) Multiome 558
chr11:554,380–556,321 72.0 kb Distal (>10kb) Multiome 460
chr11:559,830–562,079 66.3 kb Distal (>10kb) Multiome 791
chr11:567,850–569,533 58.6 kb Distal (>10kb) Multiome 672
chr11:574,830–576,748 51.1 kb Distal (>10kb) Multiome 793
chr11:613,334–614,059 13.5 kb Distal (>10kb) Multiome 215
chr11:615,262–616,320 11.3 kb Distal (>10kb) Multiome 443
chr11:636,786–637,700 10.0 kb Proximal (<10kb) Multiome 161
chr11:693,835–696,330 68.3 kb Distal (>10kb) Multiome 873
chr11:705,737–706,270 78.9 kb Distal (>10kb) Multiome 361
chr11:720,619–721,074 93.7 kb Distal (>10kb) Multiome 156
chr11:727,901–728,499 101.0 kb Distal (>10kb) Multiome 686
chr11:746,704–748,069 120.1 kb Distal (>10kb) Multiome 755
chr11:762,582–763,602 136.1 kb Distal (>10kb) Multiome 326
chr11:776,216–778,328 150.2 kb Distal (>10kb) Multiome 770
chr11:783,385–783,909 156.5 kb Distal (>10kb) Multiome 278
chr11:797,112–798,675 171.1 kb Distal (>10kb) Multiome 697
chr11:804,241–805,812 178.1 kb Distal (>10kb) Multiome 725
chr11:808,894–810,402 182.5 kb Distal (>10kb) Multiome 976
chr11:818,369–820,592 192.4 kb Distal (>10kb) Multiome 749
chr11:826,980–828,116 200.4 kb Distal (>10kb) Multiome 662
chr11:828,933–831,262 203.2 kb Distal (>10kb) Multiome 491
chr11:832,323–833,565 205.7 kb Distal (>10kb) Multiome 562
chr11:842,034–843,556 215.5 kb Distal (>10kb) Multiome 794
chr11:843,773–845,220 217.3 kb Distal (>10kb) Multiome 664
chr11:849,082–850,270 222.6 kb Distal (>10kb) Multiome 229
chr11:910,337–911,591 283.8 kb Distal (>10kb) Multiome 754
chr11:925,038–926,264 298.7 kb Distal (>10kb) Multiome 689

Genome Browser

Genomic view of the SCT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr11:323,722 – 936,264
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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