Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog to the yeast SCO1 gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SCO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:10,697,052–10,698,025 | 81 bp | At TSS Multiome | 852 | |
| chr17:10,729,418–10,730,194 | 32.4 kb | Distal (>10kb) Multiome | 604 | |
| chr17:10,754,906–10,755,615 | 57.8 kb | Distal (>10kb) Multiome | 62 | |
| chr17:10,844,622–10,845,447 | 147.6 kb | Distal (>10kb) Multiome | 298 | |
| chr17:10,936,641–10,937,774 | 239.6 kb | Distal (>10kb) Multiome | 142 | |
| chr17:11,598,120–11,599,444 | 901.5 kb | Distal (>10kb) Multiome HiCAR | 315 | |
| chr17:11,986,045–11,987,265 | 1288.9 kb | Distal (>10kb) Multiome HiCAR | 204 |
Genomic view of the SCO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.