This gene encodes an adaptor protein. Studies of a related gene in rat suggest that the encoded protein functions to link clathrin to the sodium channel protein type 10 subunit alpha protein. The encoded protein has also been identified as a component of distal appendages of centrioles that is necessary for ciliogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for SCLT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCLT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCLT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:128,802,742–128,803,879 | 290.6 kb | Distal (>10kb) Multiome | 154 | |
| chr4:128,809,374–128,810,275 | 283.9 kb | Distal (>10kb) Multiome | 764 | |
| chr4:128,810,520–128,812,873 | 281.3 kb | Distal (>10kb) Multiome | 1012 | |
| chr4:128,830,823–128,832,500 | 261.8 kb | Distal (>10kb) Multiome | 300 | |
| chr4:128,866,342–128,867,421 | 226.7 kb | Distal (>10kb) Multiome | 129 | |
| chr4:129,093,021–129,094,152 | 14 bp | At TSS Multiome | 827 | |
| chr4:129,096,037–129,096,647 | 2.5 kb | Proximal (<10kb) | 367 | |
| chr4:129,100,088–129,100,299 | 6.5 kb | Proximal (<10kb) | 2 | |
| chr4:129,164,187–129,164,904 | 70.9 kb | Distal (>10kb) Multiome | 85 | |
| chr4:129,205,784–129,206,798 | 112.8 kb | Distal (>10kb) Multiome | 121 |
Genomic view of the SCLT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.