The protein encoded by this gene is a secreted lung surfactant protein and a downstream target of thyroid transcription factor. A single nucleotide polymorphism in the promoter of this gene results in susceptibility to asthma.[provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for SCGB3A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCGB3A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCGB3A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:147,626,194–147,627,455 | 245.0 kb | Distal (>10kb) Multiome | 106 | |
| chr5:147,782,086–147,783,019 | 88.7 kb | Distal (>10kb) Multiome | 348 | |
| chr5:147,862,922–147,863,639 | 7.9 kb | Proximal (<10kb) | 24 | |
| chr5:147,864,777–147,865,131 | 6.4 kb | Proximal (<10kb) | 3 | |
| chr5:147,868,433–147,870,551 | 2.4 kb | Proximal (<10kb) Multiome HiCAR | 335 | |
| chr5:147,872,851–147,873,158 | 1.4 kb | Proximal (<10kb) | 11 | |
| chr5:147,873,930–147,875,597 | 3.0 kb | Proximal (<10kb) Multiome | 295 | |
| chr5:148,005,921–148,006,546 | 134.8 kb | Distal (>10kb) Multiome | 86 | |
| chr5:148,090,303–148,091,251 | 219.3 kb | Distal (>10kb) Multiome | 206 |
Genomic view of the SCGB3A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.