The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Transcription factors with Perturb-seq knockdown data for SCG3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCG3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCG3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:51,407,071–51,407,878 | 274.1 kb | Distal (>10kb) Multiome | 99 | |
| chr15:51,621,891–51,623,295 | 58.6 kb | Distal (>10kb) Multiome | 786 | |
| chr15:51,681,155–51,681,883 | 29 bp | At TSS Multiome | 662 | |
| chr15:51,726,326–51,726,848 | 45.0 kb | Distal (>10kb) Multiome | 334 | |
| chr15:51,736,980–51,738,047 | 56.1 kb | Distal (>10kb) Multiome | 521 | |
| chr15:51,751,070–51,752,267 | 70.1 kb | Distal (>10kb) Multiome | 433 | |
| chr15:51,829,316–51,830,426 | 148.3 kb | Distal (>10kb) Multiome | 787 | |
| chr15:51,971,175–51,972,397 | 290.3 kb | Distal (>10kb) Multiome | 887 |
Genomic view of the SCG3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.