This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17. [provided by RefSeq, Sep 2015]
Transcription factors with Perturb-seq knockdown data for SCD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:100,185,381–100,186,650 | 161.2 kb | Distal (>10kb) Multiome | 913 | |
| chr10:100,228,957–100,229,948 | 117.7 kb | Distal (>10kb) Multiome | 759 | |
| chr10:100,267,386–100,267,986 | 79.5 kb | Distal (>10kb) Multiome | 715 | |
| chr10:100,286,018–100,287,021 | 60.6 kb | Distal (>10kb) Multiome | 849 | |
| chr10:100,338,528–100,338,725 | 8.5 kb | Proximal (<10kb) | 212 | |
| chr10:100,342,435–100,342,690 | 4.5 kb | Proximal (<10kb) | 406 | |
| chr10:100,346,401–100,347,640 | 364 bp | At TSS Multiome | 919 | |
| chr10:100,359,067–100,359,724 | 12.0 kb | Distal (>10kb) Multiome | 425 | |
| chr10:100,372,854–100,374,386 | 26.3 kb | Distal (>10kb) Multiome | 964 | |
| chr10:100,481,576–100,482,049 | 134.4 kb | Distal (>10kb) Multiome | 298 | |
| chr10:100,482,268–100,483,078 | 135.6 kb | Distal (>10kb) Multiome | 497 | |
| chr10:100,485,778–100,486,586 | 138.9 kb | Distal (>10kb) Multiome | 161 | |
| chr10:100,518,832–100,519,948 | 172.2 kb | Distal (>10kb) Multiome HiCAR | 417 | |
| chr10:100,529,444–100,530,236 | 182.7 kb | Distal (>10kb) Multiome | 619 | |
| chr10:100,535,502–100,536,234 | 188.7 kb | Distal (>10kb) Multiome | 759 | |
| chr10:100,561,994–100,562,629 | 214.9 kb | Distal (>10kb) Multiome | 491 |
Genomic view of the SCD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.