This gene encodes a SCAN box domain-containing protein. The SCAN domain is a highly conserved, leucine-rich motif of approximately 60 aa originally found within a subfamily of zinc finger proteins. This gene belongs to a family of genes that encode an isolated SCAN domain, but no zinc finger motif. This protein binds to and may regulate the function of the transcription factor myeloid zinc finger 1B. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for SCAND1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCAND1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCAND1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:35,664,428–35,665,171 | 289.6 kb | Distal (>10kb) Multiome | 1018 | |
| chr20:35,698,724–35,699,893 | 255.1 kb | Distal (>10kb) Multiome | 1035 | |
| chr20:35,741,564–35,742,903 | 212.1 kb | Distal (>10kb) Multiome | 1145 | |
| chr20:35,769,101–35,769,560 | 185.2 kb | Distal (>10kb) Multiome | 415 | |
| chr20:35,771,622–35,772,463 | 182.4 kb | Distal (>10kb) Multiome | 998 | |
| chr20:35,953,663–35,955,230 | 76 bp | At TSS Multiome | 1166 | |
| chr20:36,010,700–36,011,324 | 56.5 kb | Distal (>10kb) Multiome | 70 | |
| chr20:36,050,468–36,051,316 | 96.5 kb | Distal (>10kb) Multiome | 1033 | |
| chr20:36,064,282–36,065,619 | 110.3 kb | Distal (>10kb) Multiome | 798 | |
| chr20:36,092,411–36,092,942 | 138.1 kb | Distal (>10kb) Multiome | 320 | |
| chr20:36,154,232–36,155,251 | 200.1 kb | Distal (>10kb) Multiome HiCAR | 526 |
Genomic view of the SCAND1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.