This gene encodes an integral membrane protein that belongs to the secretory carrier membrane protein family. The encoded protein functions as a carrier to the cell surface in post-golgi recycling pathways. This protein is also involved in protein trafficking in endosomal pathways. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
Transcription factors with Perturb-seq knockdown data for SCAMP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCAMP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCAMP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:154,961,269–154,962,529 | 300.6 kb | Distal (>10kb) Multiome | 985 | |
| chr1:154,970,161–154,971,641 | 291.5 kb | Distal (>10kb) Multiome | 535 | |
| chr1:154,972,362–154,975,914 | 287.8 kb | Distal (>10kb) Multiome | 1085 | |
| chr1:154,982,968–154,983,632 | 279.1 kb | Distal (>10kb) Multiome | 693 | |
| chr1:154,998,961–155,004,423 | 263.0 kb | Distal (>10kb) Multiome | 1210 | |
| chr1:155,017,084–155,017,941 | 244.9 kb | Distal (>10kb) Multiome | 1003 | |
| chr1:155,050,292–155,052,078 | 211.1 kb | Distal (>10kb) Multiome | 948 | |
| chr1:155,061,415–155,064,552 | 198.4 kb | Distal (>10kb) Multiome | 860 | |
| chr1:155,070,748–155,071,423 | 191.3 kb | Distal (>10kb) Multiome | 542 | |
| chr1:155,078,524–155,079,535 | 183.5 kb | Distal (>10kb) Multiome | 397 | |
| chr1:155,079,852–155,081,529 | 181.4 kb | Distal (>10kb) Multiome | 539 | |
| chr1:155,084,373–155,086,501 | 177.3 kb | Distal (>10kb) Multiome | 865 | |
| chr1:155,091,315–155,091,900 | 170.8 kb | Distal (>10kb) Multiome | 594 | |
| chr1:155,126,247–155,126,903 | 135.9 kb | Distal (>10kb) Multiome | 776 | |
| chr1:155,127,607–155,128,120 | 134.5 kb | Distal (>10kb) Multiome | 578 | |
| chr1:155,135,100–155,136,750 | 126.5 kb | Distal (>10kb) Multiome | 938 | |
| chr1:155,166,847–155,168,170 | 94.5 kb | Distal (>10kb) Multiome | 622 | |
| chr1:155,172,629–155,174,979 | 89.1 kb | Distal (>10kb) Multiome | 903 | |
| chr1:155,192,921–155,194,099 | 68.8 kb | Distal (>10kb) Multiome | 755 | |
| chr1:155,194,230–155,195,403 | 67.5 kb | Distal (>10kb) Multiome | 753 | |
| chr1:155,196,127–155,196,592 | 66.0 kb | Distal (>10kb) Multiome | 97 | |
| chr1:155,207,822–155,209,789 | 53.4 kb | Distal (>10kb) Multiome | 826 | |
| chr1:155,226,522–155,227,197 | 35.8 kb | Distal (>10kb) Multiome | 600 | |
| chr1:155,227,312–155,228,116 | 34.7 kb | Distal (>10kb) Multiome | 688 | |
| chr1:155,244,103–155,245,349 | 17.6 kb | Distal (>10kb) Multiome | 900 | |
| chr1:155,250,356–155,251,199 | 11.5 kb | Distal (>10kb) Multiome | 605 | |
| chr1:155,255,032–155,255,921 | 6.8 kb | Proximal (<10kb) Multiome | 661 | |
| chr1:155,261,679–155,262,788 | 1 bp | At TSS Multiome | 921 | |
| chr1:155,272,928–155,274,098 | 11.2 kb | Distal (>10kb) Multiome | 768 | |
| chr1:155,276,933–155,278,884 | 16.2 kb | Distal (>10kb) Multiome | 749 | |
| chr1:155,308,291–155,309,348 | 46.4 kb | Distal (>10kb) Multiome | 934 | |
| chr1:155,320,564–155,321,470 | 58.5 kb | Distal (>10kb) Multiome | 341 | |
| chr1:155,322,680–155,325,643 | 62.0 kb | Distal (>10kb) Multiome | 979 |
Genomic view of the SCAMP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.