This gene product belongs to the SCAMP family of proteins which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Transcription factors with Perturb-seq knockdown data for SCAMP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCAMP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCAMP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:74,598,102–74,598,966 | 274.9 kb | Distal (>10kb) Multiome | 689 | |
| chr15:74,614,343–74,616,348 | 257.6 kb | Distal (>10kb) Multiome | 1019 | |
| chr15:74,695,758–74,696,387 | 177.3 kb | Distal (>10kb) Multiome | 775 | |
| chr15:74,720,336–74,720,840 | 152.7 kb | Distal (>10kb) Multiome | 16 | |
| chr15:74,725,773–74,726,537 | 147.2 kb | Distal (>10kb) Multiome | 607 | |
| chr15:74,759,107–74,760,837 | 113.0 kb | Distal (>10kb) Multiome | 637 | |
| chr15:74,761,837–74,762,260 | 111.2 kb | Distal (>10kb) Multiome | 34 | |
| chr15:74,770,975–74,771,578 | 102.0 kb | Distal (>10kb) Multiome | 485 | |
| chr15:74,781,439–74,783,648 | 91.3 kb | Distal (>10kb) Multiome | 679 | |
| chr15:74,842,412–74,843,723 | 30.3 kb | Distal (>10kb) Multiome | 879 | |
| chr15:74,872,771–74,874,092 | 82 bp | At TSS Multiome | 758 | |
| chr15:74,889,894–74,890,629 | 16.7 kb | Distal (>10kb) Multiome | 816 | |
| chr15:74,905,926–74,907,376 | 33.5 kb | Distal (>10kb) Multiome | 743 | |
| chr15:74,937,494–74,938,710 | 64.8 kb | Distal (>10kb) Multiome | 998 | |
| chr15:74,950,147–74,950,911 | 77.3 kb | Distal (>10kb) Multiome | 326 | |
| chr15:74,954,536–74,955,001 | 81.4 kb | Distal (>10kb) Multiome | 348 | |
| chr15:74,955,873–74,957,720 | 83.5 kb | Distal (>10kb) Multiome | 776 | |
| chr15:74,958,363–74,959,586 | 85.3 kb | Distal (>10kb) Multiome | 282 | |
| chr15:74,995,116–74,996,280 | 122.2 kb | Distal (>10kb) Multiome | 825 | |
| chr15:75,023,365–75,023,895 | 150.2 kb | Distal (>10kb) Multiome | 822 | |
| chr15:75,140,133–75,140,707 | 267.1 kb | Distal (>10kb) Multiome | 536 |
Genomic view of the SCAMP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.