This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
Transcription factors with Perturb-seq knockdown data for SCAI. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCAI upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCAI, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:124,852,683–124,853,882 | 290.3 kb | Distal (>10kb) Multiome | 666 | |
| chr9:124,855,555–124,856,920 | 287.3 kb | Distal (>10kb) Multiome | 402 | |
| chr9:124,861,378–124,862,662 | 281.4 kb | Distal (>10kb) Multiome | 947 | |
| chr9:124,868,442–124,869,814 | 274.4 kb | Distal (>10kb) Multiome | 849 | |
| chr9:124,940,496–124,941,902 | 202.4 kb | Distal (>10kb) Multiome | 979 | |
| chr9:125,142,890–125,144,084 | 111 bp | At TSS Multiome | 723 | |
| chr9:125,189,173–125,190,290 | 46.4 kb | Distal (>10kb) Multiome | 830 | |
| chr9:125,199,947–125,201,039 | 57.0 kb | Distal (>10kb) Multiome | 866 | |
| chr9:125,240,934–125,242,115 | 98.0 kb | Distal (>10kb) Multiome | 974 | |
| chr9:125,261,500–125,262,311 | 118.3 kb | Distal (>10kb) Multiome | 900 | |
| chr9:125,407,852–125,408,856 | 264.8 kb | Distal (>10kb) Multiome | 615 |
Genomic view of the SCAI locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.