This gene encodes a pseudophosphatase and member of the myotubularin-related protein family. This gene maps within the CMT4B2 candidate region of chromosome 11p15 and mutations in this gene have been associated with Charcot-Marie-Tooth Disease, type 4B2. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SBF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SBF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SBF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:9,613,193–9,614,617 | 690.7 kb | Distal (>10kb) Multiome HiCAR | 997 | |
| chr11:9,757,927–9,759,329 | 546.6 kb | Distal (>10kb) Multiome HiCAR | 865 | |
| chr11:9,922,650–9,923,161 | 381.9 kb | Distal (>10kb) Multiome | 154 | |
| chr11:9,982,795–9,983,783 | 321.6 kb | Distal (>10kb) Multiome | 255 | |
| chr11:10,051,948–10,052,195 | 7.3 kb | Proximal (<10kb) | 56 | |
| chr11:10,293,485–10,294,954 | 10.8 kb | Distal (>10kb) Multiome | 728 | |
| chr11:10,302,521–10,303,802 | 8.3 kb | Proximal (<10kb) | 595 | |
| chr11:10,303,927–10,306,992 | 54 bp | At TSS Multiome | 897 | |
| chr11:10,307,252–10,308,323 | 3.1 kb | Proximal (<10kb) Multiome | 800 | |
| chr11:10,309,037–10,310,838 | 4.8 kb | Proximal (<10kb) Multiome | 494 | |
| chr11:10,351,409–10,352,676 | 47.1 kb | Distal (>10kb) Multiome | 677 | |
| chr11:10,450,400–10,451,424 | 146.2 kb | Distal (>10kb) Multiome | 419 | |
| chr11:10,455,858–10,456,376 | 151.2 kb | Distal (>10kb) Multiome | 394 | |
| chr11:10,540,488–10,541,619 | 236.3 kb | Distal (>10kb) Multiome | 859 |
Genomic view of the SBF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.