This gene belongs to the class II amino-acyl tRNA family. The encoded enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown. [provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for SARS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SARS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SARS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:108,963,024–108,963,620 | 250.5 kb | Distal (>10kb) Multiome | 906 | |
| chr1:109,041,106–109,042,646 | 171.8 kb | Distal (>10kb) Multiome | 792 | |
| chr1:109,075,733–109,076,324 | 137.8 kb | Distal (>10kb) Multiome | 864 | |
| chr1:109,090,360–109,091,274 | 123.1 kb | Distal (>10kb) Multiome | 1016 | |
| chr1:109,099,660–109,100,771 | 113.8 kb | Distal (>10kb) Multiome | 1149 | |
| chr1:109,112,499–109,113,189 | 101.1 kb | Distal (>10kb) Multiome | 536 | |
| chr1:109,113,744–109,114,449 | 99.7 kb | Distal (>10kb) Multiome | 236 | |
| chr1:109,213,499–109,214,619 | 19 bp | At TSS Multiome | 770 | |
| chr1:109,214,894–109,215,090 | 977 bp | At TSS | 456 | |
| chr1:109,229,475–109,230,215 | 16.0 kb | Distal (>10kb) Multiome | 221 | |
| chr1:109,240,604–109,241,116 | 27.1 kb | Distal (>10kb) Multiome | 391 | |
| chr1:109,249,055–109,250,364 | 35.6 kb | Distal (>10kb) Multiome | 527 | |
| chr1:109,263,250–109,264,042 | 49.8 kb | Distal (>10kb) Multiome | 767 | |
| chr1:109,282,693–109,283,858 | 69.3 kb | Distal (>10kb) Multiome | 850 | |
| chr1:109,306,995–109,308,024 | 93.7 kb | Distal (>10kb) Multiome | 425 | |
| chr1:109,397,369–109,398,671 | 184.1 kb | Distal (>10kb) Multiome | 654 | |
| chr1:109,425,842–109,427,054 | 212.6 kb | Distal (>10kb) Multiome | 922 | |
| chr1:109,466,294–109,467,385 | 252.7 kb | Distal (>10kb) Multiome | 452 | |
| chr1:109,483,147–109,484,806 | 270.0 kb | Distal (>10kb) Multiome | 1031 | |
| chr1:109,493,695–109,494,597 | 280.2 kb | Distal (>10kb) Multiome | 842 | |
| chr1:109,498,180–109,498,608 | 284.5 kb | Distal (>10kb) Multiome | 178 | |
| chr1:109,509,196–109,510,011 | 295.8 kb | Distal (>10kb) Multiome | 448 |
Genomic view of the SARS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.