Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008]
Transcription factors with Perturb-seq knockdown data for SAP18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SAP18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SAP18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:20,902,026–20,903,305 | 237.7 kb | Distal (>10kb) Multiome | 749 | |
| chr13:21,060,253–21,061,988 | 79.0 kb | Distal (>10kb) Multiome | 817 | |
| chr13:21,075,367–21,076,193 | 64.8 kb | Distal (>10kb) Multiome | 151 | |
| chr13:21,139,877–21,141,067 | 112 bp | At TSS Multiome | 784 | |
| chr13:21,176,109–21,177,241 | 36.1 kb | Distal (>10kb) Multiome | 933 | |
| chr13:21,297,800–21,298,863 | 157.6 kb | Distal (>10kb) Multiome | 776 | |
| chr13:21,326,200–21,327,030 | 186.0 kb | Distal (>10kb) Multiome | 179 | |
| chr13:21,410,303–21,410,800 | 270.0 kb | Distal (>10kb) Multiome | 76 |
Genomic view of the SAP18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.