This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for SAMHD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SAMHD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SAMHD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:36,676,551–36,678,157 | 274.5 kb | Distal (>10kb) Multiome | 370 | |
| chr20:36,745,462–36,746,528 | 205.5 kb | Distal (>10kb) Multiome | 739 | |
| chr20:36,773,223–36,774,655 | 177.7 kb | Distal (>10kb) Multiome | 971 | |
| chr20:36,835,484–36,836,113 | 115.9 kb | Distal (>10kb) Multiome | 446 | |
| chr20:36,863,126–36,864,425 | 87.8 kb | Distal (>10kb) Multiome | 833 | |
| chr20:36,886,953–36,887,714 | 64.3 kb | Distal (>10kb) Multiome | 586 | |
| chr20:36,947,063–36,947,335 | 4.3 kb | Proximal (<10kb) | 120 | |
| chr20:36,951,062–36,952,347 | 124 bp | At TSS Multiome | 859 | |
| chr20:37,095,487–37,096,500 | 144.2 kb | Distal (>10kb) Multiome | 1181 | |
| chr20:37,178,598–37,179,693 | 227.4 kb | Distal (>10kb) Multiome | 977 |
Genomic view of the SAMHD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.