Predicted to enable ceramide cholinephosphotransferase activity and sphingomyelin synthase activity. Involved in ceramide biosynthetic process and regulation of ceramide biosynthetic process. Located in cytosol and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for SAMD8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SAMD8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SAMD8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:74,150,306–74,151,881 | 960.3 kb | Distal (>10kb) Multiome HiCAR | 926 | |
| chr10:74,176,195–74,177,295 | 934.9 kb | Distal (>10kb) Multiome HiCAR | 1072 | |
| chr10:74,813,288–74,813,763 | 297.9 kb | Distal (>10kb) Multiome | 140 | |
| chr10:74,824,308–74,827,412 | 285.1 kb | Distal (>10kb) Multiome | 1014 | |
| chr10:74,921,339–74,922,280 | 189.7 kb | Distal (>10kb) Multiome | 350 | |
| chr10:75,043,531–75,044,056 | 67.7 kb | Distal (>10kb) Multiome | 156 | |
| chr10:75,058,930–75,059,944 | 52.0 kb | Distal (>10kb) Multiome | 137 | |
| chr10:75,079,403–75,080,508 | 31.7 kb | Distal (>10kb) Multiome | 189 | |
| chr10:75,099,885–75,100,763 | 11.4 kb | Distal (>10kb) Multiome | 419 | |
| chr10:75,106,213–75,106,749 | 4.8 kb | Proximal (<10kb) | 82 | |
| chr10:75,108,500–75,109,317 | 2.2 kb | Proximal (<10kb) | 374 | |
| chr10:75,111,043–75,112,358 | 22 bp | At TSS Multiome | 857 | |
| chr10:75,188,012–75,188,453 | 76.7 kb | Distal (>10kb) Multiome | 268 | |
| chr10:75,206,644–75,207,978 | 96.0 kb | Distal (>10kb) Multiome | 207 | |
| chr10:75,209,910–75,211,260 | 99.1 kb | Distal (>10kb) Multiome | 1059 | |
| chr10:75,233,116–75,236,429 | 124.5 kb | Distal (>10kb) Multiome HiCAR | 1015 | |
| chr10:75,294,540–75,295,659 | 183.6 kb | Distal (>10kb) Multiome | 702 | |
| chr10:75,395,145–75,397,482 | 285.7 kb | Distal (>10kb) Multiome | 341 | |
| chr10:75,398,678–75,400,431 | 288.4 kb | Distal (>10kb) Multiome | 501 | |
| chr10:75,400,704–75,404,045 | 290.6 kb | Distal (>10kb) Multiome | 978 | |
| chr10:75,404,151–75,405,735 | 293.7 kb | Distal (>10kb) Multiome | 760 | |
| chr10:75,408,986–75,410,039 | 298.0 kb | Distal (>10kb) Multiome | 639 |
Genomic view of the SAMD8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.