This gene encodes a zinc finger transcription factor thought to play a role in the development of abducens motor neurons. Defects in this gene are a cause of Duane-radial ray syndrome (DRRS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for SALL4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SALL4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SALL4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:51,542,047–51,542,945 | 259.8 kb | Distal (>10kb) Multiome | 490 | |
| chr20:51,562,201–51,563,176 | 239.9 kb | Distal (>10kb) Multiome | 525 | |
| chr20:51,766,950–51,768,471 | 35.1 kb | Distal (>10kb) Multiome | 740 | |
| chr20:51,797,358–51,798,525 | 4.6 kb | Proximal (<10kb) Multiome | 273 | |
| chr20:51,799,751–51,800,876 | 2.0 kb | Proximal (<10kb) Multiome | 661 | |
| chr20:51,801,027–51,803,202 | 138 bp | At TSS Multiome | 615 | |
| chr20:51,810,228–51,810,726 | 8.6 kb | Proximal (<10kb) | 92 | |
| chr20:52,049,182–52,049,698 | 247.1 kb | Distal (>10kb) Multiome | 141 |
Genomic view of the SALL4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.