The protein encoded by this gene, along with its paralog (scaffold attachment factor B1), is a repressor of estrogen receptor alpha. The encoded protein binds scaffold/matrix attachment region (S/MAR) DNA and is involved in cell cycle regulation, apoptosis, differentiation, the stress response, and regulation of immune genes. [provided by RefSeq, May 2016]
Transcription factors with Perturb-seq knockdown data for SAFB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SAFB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SAFB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:4,534,817–4,535,416 | 1087.5 kb | Distal (>10kb) Multiome HiCAR | 451 | |
| chr19:5,339,639–5,341,408 | 281.9 kb | Distal (>10kb) Multiome | 966 | |
| chr19:5,397,820–5,398,866 | 224.4 kb | Distal (>10kb) Multiome | 137 | |
| chr19:5,436,304–5,437,277 | 186.0 kb | Distal (>10kb) Multiome | 227 | |
| chr19:5,536,326–5,536,869 | 86.1 kb | Distal (>10kb) Multiome | 306 | |
| chr19:5,567,504–5,568,201 | 55.0 kb | Distal (>10kb) Multiome | 209 | |
| chr19:5,585,656–5,586,338 | 36.8 kb | Distal (>10kb) Multiome | 267 | |
| chr19:5,621,964–5,623,739 | 167 bp | At TSS Multiome | 857 | |
| chr19:5,679,757–5,681,464 | 58.0 kb | Distal (>10kb) Multiome | 884 | |
| chr19:5,686,329–5,687,994 | 64.3 kb | Distal (>10kb) Multiome | 693 | |
| chr19:5,689,735–5,690,874 | 67.5 kb | Distal (>10kb) Multiome | 960 | |
| chr19:5,719,717–5,721,174 | 97.6 kb | Distal (>10kb) Multiome | 985 | |
| chr19:5,790,527–5,791,509 | 168.1 kb | Distal (>10kb) Multiome | 965 | |
| chr19:5,803,750–5,806,128 | 182.4 kb | Distal (>10kb) Multiome | 858 | |
| chr19:5,826,528–5,829,726 | 205.3 kb | Distal (>10kb) Multiome | 1037 | |
| chr19:5,903,474–5,905,358 | 281.8 kb | Distal (>10kb) Multiome | 1027 |
Genomic view of the SAFB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.