Acts upstream of or within positive regulation of synoviocyte proliferation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SAAL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SAAL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SAAL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:18,012,267–18,014,143 | 93.0 kb | Distal (>10kb) Multiome | 838 | |
| chr11:18,105,744–18,106,263 | 14 bp | At TSS Multiome | 873 | |
| chr11:18,107,786–18,107,948 | 1.7 kb | Proximal (<10kb) | 6 | |
| chr11:18,115,557–18,115,960 | 9.5 kb | Proximal (<10kb) | 304 | |
| chr11:18,318,016–18,318,522 | 212.2 kb | Distal (>10kb) Multiome | 49 | |
| chr11:18,321,766–18,322,926 | 216.3 kb | Distal (>10kb) Multiome | 1044 | |
| chr11:18,393,759–18,396,665 | 290.1 kb | Distal (>10kb) Multiome | 1203 |
Genomic view of the SAAL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.