Members of the S100 protein family contain 2 calcium-binding EF-hands and exhibit cell-type specific expression patterns. For additional background information on S100 proteins, see MIM 114085.[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for S100Z. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = S100Z upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of S100Z, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:76,715,026–76,716,740 | 159.2 kb | Distal (>10kb) Multiome | 666 | |
| chr5:76,789,270–76,790,249 | 85.4 kb | Distal (>10kb) Multiome | 123 | |
| chr5:76,818,476–76,819,940 | 56.3 kb | Distal (>10kb) Multiome | 686 | |
| chr5:76,868,126–76,868,382 | 6.9 kb | Proximal (<10kb) | 187 | |
| chr5:76,873,943–76,874,791 | 895 bp | At TSS Multiome | 261 | |
| chr5:76,953,306–76,954,445 | 78.5 kb | Distal (>10kb) Multiome HiCAR | 235 | |
| chr5:77,030,193–77,031,058 | 155.1 kb | Distal (>10kb) Multiome HiCAR | 903 | |
| chr5:77,076,843–77,078,059 | 202.3 kb | Distal (>10kb) Multiome HiCAR | 396 | |
| chr5:77,086,556–77,087,540 | 211.6 kb | Distal (>10kb) Multiome | 768 |
Genomic view of the S100Z locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.