The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for S100A6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = S100A6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of S100A6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:153,260,802–153,262,055 | 274.8 kb | Distal (>10kb) Multiome | 209 | |
| chr1:153,494,904–153,495,543 | 41.1 kb | Distal (>10kb) Multiome | 290 | |
| chr1:153,532,833–153,533,594 | 3.0 kb | Proximal (<10kb) Multiome | 493 | |
| chr1:153,538,198–153,538,657 | 2.2 kb | Proximal (<10kb) Multiome | 338 | |
| chr1:153,544,844–153,545,543 | 9.0 kb | Proximal (<10kb) Multiome | 575 | |
| chr1:153,568,278–153,569,058 | 32.4 kb | Distal (>10kb) Multiome | 641 | |
| chr1:153,626,535–153,627,974 | 91.3 kb | Distal (>10kb) Multiome | 697 | |
| chr1:153,633,575–153,634,639 | 97.8 kb | Distal (>10kb) Multiome | 998 | |
| chr1:153,658,331–153,659,230 | 122.5 kb | Distal (>10kb) Multiome | 746 | |
| chr1:153,670,709–153,671,992 | 134.9 kb | Distal (>10kb) Multiome | 884 | |
| chr1:153,697,776–153,698,654 | 162.0 kb | Distal (>10kb) Multiome | 313 | |
| chr1:153,727,492–153,728,827 | 191.7 kb | Distal (>10kb) Multiome | 702 | |
| chr1:153,745,487–153,745,959 | 209.4 kb | Distal (>10kb) Multiome | 55 | |
| chr1:153,774,962–153,776,698 | 239.9 kb | Distal (>10kb) Multiome | 671 | |
| chr1:153,783,341–153,784,300 | 247.5 kb | Distal (>10kb) Multiome | 794 |
Genomic view of the S100A6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.