This gene encodes a putative transmembrane protein containing a conserved DUF647 domain that may be involved in protein-protein interaction. The encoded protein is related to a plant protein that participates in ultraviolet B light-sensing during root morphogenesis. [provided by RefSeq, Feb 2013]
Transcription factors with Perturb-seq knockdown data for RUSF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RUSF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RUSF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:31,214,606–31,216,091 | 293.1 kb | Distal (>10kb) Multiome | 469 | |
| chr16:31,406,131–31,406,947 | 101.9 kb | Distal (>10kb) Multiome | 214 | |
| chr16:31,442,550–31,443,636 | 65.3 kb | Distal (>10kb) Multiome | 838 | |
| chr16:31,457,952–31,460,456 | 50.3 kb | Distal (>10kb) Multiome | 1128 | |
| chr16:31,471,780–31,473,168 | 35.5 kb | Distal (>10kb) Multiome | 425 | |
| chr16:31,476,391–31,478,207 | 30.6 kb | Distal (>10kb) Multiome | 750 | |
| chr16:31,487,298–31,488,862 | 20.5 kb | Distal (>10kb) Multiome | 323 | |
| chr16:31,507,726–31,508,748 | 40 bp | At TSS Multiome | 992 | |
| chr16:31,529,299–31,530,211 | 21.3 kb | Distal (>10kb) Multiome | 114 | |
| chr16:31,700,204–31,701,065 | 192.2 kb | Distal (>10kb) Multiome HiCAR | 787 | |
| chr16:31,712,839–31,714,180 | 204.9 kb | Distal (>10kb) Multiome HiCAR | 930 |
Genomic view of the RUSF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.