This gene encodes a RUN and SH3 domain containing protein that interacts with Rab1b and Rab1-binding protein GM130. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2012]
Transcription factors with Perturb-seq knockdown data for RUSC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RUSC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RUSC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:35,406,111–35,407,050 | 83.5 kb | Distal (>10kb) Multiome | 145 | |
| chr9:35,424,217–35,425,184 | 65.4 kb | Distal (>10kb) Multiome | 171 | |
| chr9:35,489,223–35,490,919 | 151 bp | At TSS Multiome | 918 | |
| chr9:35,603,584–35,606,173 | 114.1 kb | Distal (>10kb) Multiome | 918 | |
| chr9:35,645,821–35,647,298 | 155.8 kb | Distal (>10kb) Multiome | 734 | |
| chr9:35,657,275–35,659,114 | 167.9 kb | Distal (>10kb) Multiome | 1156 | |
| chr9:35,664,903–35,665,580 | 175.1 kb | Distal (>10kb) Multiome | 814 | |
| chr9:35,675,371–35,676,451 | 185.8 kb | Distal (>10kb) Multiome | 223 | |
| chr9:35,689,224–35,691,525 | 201.1 kb | Distal (>10kb) Multiome | 541 | |
| chr9:35,731,682–35,733,531 | 242.2 kb | Distal (>10kb) Multiome | 920 | |
| chr9:35,748,884–35,750,005 | 259.2 kb | Distal (>10kb) Multiome | 667 | |
| chr9:35,756,620–35,757,642 | 266.9 kb | Distal (>10kb) Multiome | 810 |
Genomic view of the RUSC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.